Talk:Morphine

Need for expert attention

@Doc James: I would recommend you find a good chemist to look at the chemistry section of the Morphine article. I moved the chemical synthesis out, because that description is okay (better, were it based on reviews, but at least it is sourced). But the real issue is that the chemistry section—which reads as naive—is, moreover, completely unsourced. (I removed the only two prior citations, one to a high school web page, and the other to a college class handout, as inapproproate for such an important substance with such a rich literature.) Were I a logging editor, I would have taken the whole thing out, as suspected plagiarism, and on the basis of its misstatements (so rampant it is with vagaries and inaccuracies). Instead, I "hid" 2-3 glaring examples (not even the most glaring), and indicated the problem with a section tag. [ a former prof.] 2601:246:C700:19D:E50A:9B38:6680:3C78 (talk) 20:59, 7 February 2020 (UTC)

Feel free to keep working on it :-) Not really my area of interest. If you see stuff that is unreferenced and incorrect feel free to remove it. Doc James (talk · contribs · email) 00:30, 8 February 2020 (UTC)

I tweaked a few of these articles - I often think many WP articles really should not have the synthetic pathways as part of the article - at least not in the detail many are - I'm sure there is some guidance WP:MEDMOS etc., - but the target audience really is not a research biochemist - nor is it often a clinician - though I think around 50 percent of docs., do actually use WP fairly frequently.

Cheers Dr. BeingObjective (talk) 15:55, 10 November 2023 (UTC)

Dose

Wow. This is a really bad article. Administration - check it out: IV isn't one of the routes!!! WHAT?? Check it out - it is claimed that it last 3-7 hrs but I had no problem finding a source that said it was effective for 24 hrs (epidurally). I don't think it's true that there is a meaningful number range for its effects. First because of the wide variety of routes of administration, and secondly because different people can have different responses (both due to genetics, habituation, health, and other factors). 98.17.44.45 (talk) 18:40, 15 October 2023 (UTC)

In the sidebar, IV is specifically mentioned in Routes of Administration.

I am not surprised that duration of action from epidural administration greatly differs from oral/parenteral (systemic) administration. I think it would be reasonable to list the epidural duration of action (sourced) in addition to the 3-7 hour claim for systemic administration. The 3-7 hours claim from drugs.com is:

Following oral, rectal, sub-Q, IM, or IV administration, analgesia may be maintained up to 7 hours.

The second source on the duration of action, Rockwood and Wilkins' fractures in children, does say duration of action is typically 3-4 hours. As such I think it's reasonable to say 3-7 hours. Of note: the archived link for the book source is dead over at archive.org, but the live version is still available.

The "different people can have different responses" is an issue with all drugs, and is part of why a range is given for duration of action; the Pharmacokinetics section already mentions these factors specifically.

Kimen8 (talk) 19:54, 15 October 2023 (UTC)

Morphine and vomiting

From personal experience, vomiting caused by Morphine wouldnt happen if you eat something, before taking it. Or if you take lower doses of it. But aside from that, Morphine doesnt exist in tablets in many places, including in my country Israel. They only give it by injection here in Israel, and only for people who are going to die, or, have Cancer. Can this be added? Noam111g (talk) 03:25, 10 November 2023 (UTC)

Morphine as a last resort

Morphine is probably the most terrible medication in the world when it comes to addiction. It also has terrible side effects, so I was wondering if we can add something of that nature. Its used as a last resort, as they say. I've seen people in hospitals in Israel my country, begging nurses for Morphine and not getting it. They were in bed going to die, but they were only given Morphine when they screamed from pain. Noam111g (talk) 03:27, 10 November 2023 (UTC)

It is a potent pain medication - therapeutically a valuable compound. There is nothing 'last resort' about it - if you have terminal cancer or chronic pain - it is essential. Used in trauma, heart disease and other serious conditions. Morphine is also a broad class of compounds and it would make little sense to chose one compounds over another and say that it is a therapeutic of last resort.... BeingObjective (talk) 03:52, 10 November 2023 (UTC)

I see. I guess you're right. I'm shocked to hear people screaming from pain and not getting it though! Its very helpful for them. With that being said, it also have too many side effects. Noam111g (talk) 12:54, 10 November 2023 (UTC)

It is a very valid point. All of the opioids have major issues - side effects, addiction, but without opioids - many would live in unbearable pain - recall the effects of opium have been known for hundreds of years - they are not new things.

I once worked as a consulting physician in a hospice - and cancer pain is a terrible thing - even with modern opioids and delivery systems.

If someone ever develops an effective non-addictive pain med - at the level of an opioid - it would likely change much in the world of medicine - many have tried- but all of these drugs are really very similar - once they were not controlled - here in the US prior to 1870 or there abouts - laudanum was readily available - rather like a shot of whisky. BeingObjective (talk) 15:48, 10 November 2023 (UTC)

no interactions?

Some of your drug entries have extensive information on interactions of the substance in question. Morphine, one of the most used and most-studied must interact with some drugs. 70.49.18.153 (talk) 18:36, 17 April 2024 (UTC)